HPV testing in the office

Authors

DOI:

https://doi.org/10.5327/2237-4574-2024810005

Keywords:

human papillomavirus viruses, human papillomavirus DNA tests, screening

Abstract

HPV is the main cause of cervical cancer in Brazil, requiring early detection for effective monitoring. HPV vaccination and DNA-HPV testing are crucial to reduce the incidence and mortality of cervical cancer, aligned with the WHO's eradication goals by 2030. DNA-HPV testing is more sensitive than cytology and can be combined with it for spaced screening intervals. New technologies, such as extended genotyping and dual-color staining tests, are being introduced to enhance HPV detection. DNA-HPV testing is recommended in cases of atypical squamous cells of undetermined significance and for post-treatment lesion monitoring. Implementing DNA-HPV testing as primary screening can be crucial in reducing cervical cancer, in line with WHO targets, awaiting widespread adoption in Brazil.

References

Instituto Nacional de Câncer José Alencar Gomes da Silva. Estimativa 2023: incidência de câncer no Brasil. Rio de Janeiro: INCA; 2023.

World Health Organization. Global strategy to accelerate the elimination of cervical cancer as a public health problem [Internet]. Geneva: WHO; 2020. [cited 2024 Jun 16]. Available at: https://www. who.int/publications/i/item/9789240014107

Perkins RB, Guido RS, Castle PE, Chelmow D, Einstein MH, Garcia F, et al. 2019 ASCCP risk–based management consensus guidelines: updates through 2023. J Low Genit Tract Dis. 2024;28(1):3-6. https://doi.org/10.1097/LGT.0000000000000788

Wright T, Stoler MH, Behrens CM, Sharma A, Zhang G, Whirgt TL. Primary cervical cancer screening with human papillomavirus: end of study results from the ATHENA study using HPV as the first-line screening test. Gynecol Oncol. 2015;136(2):189-97. https://doi.org/10.1016/j.ygyno.2014.11.076

Speck NMG, Carvalho JP. Dossiê de estratégias do rastreamento do câncer de colo uterino no Brasil. [acessado em 2024 maio 10]. Disponível em: https://www.febrasgo.org.br/pt/noticias/item/456-dossie-de-estrategias-do-rastreamento-do-cancer-de-colo-uterino-no-brasil

Demarco M, Hyun N, Carter-Pokras O, Raine-Bennett TR, Cheung L, Chen X, et al. A study of type-specific HPV natural history and implications for contemporary cervical cancer screening programs. EClinicalMedicine. 2020;22:100293. https://doi.org/10.1016/j.eclinm.2020.100293

Arbyn M, Smith SB, Temin S, Sultana F, Castle P. Detecting cervical precancer and reaching underscreened women by using HPV testing on self samples: updated meta-analyses. BMJ. 2018;363:k4823. https://doi.org/10.1136/bmj.k4823

Wentzensen N, Garcia F, Clarke MA, Massad LS, Cheung LC, Egemen D, et al. Enduring Consensus Guidelines for Cervical Cancer Screening and Management: introduction to the scope and process. J Low Genit Tract Dis. 2024;28(2):117-23. https://doi.org/10.1097/lgt.0000000000000804

Bonde JH, Sandri MT, Gary DS, Andrews JC. Clinical utility of human papillomavirus genotyping in cervical cancer screening: a systematic review. J Low Genit Tract Dis. 2020;24(1):1-13. https://doi.org/10.1097/lgt.0000000000000494

Graça J, Preti M, Pollano B, Vieira-Baptista P. Performance of different follow-up strategies and genotype-based recurrence risk after treatment of cervical high-grade squamous intraepithelial lesion. J Low Genit Tract Dis. 2024;28(2):131-6. https://doi.org/10.1097/lgt.0000000000000803

Published

2024-09-20

How to Cite

1.
Speck NM de G. HPV testing in the office. Rev Bras Patol Trato Genit Inferior [Internet]. 2024 Sep. 20 [cited 2026 May 11];8(1). Available from: https://rbptgi.emnuvens.com.br/revista/article/view/5

Issue

Section

Letters to Editor